I actually kinda like this one. If we put aside the text only 'could be a tweet' -ness of it, I can get behind it. Since the joke is taking reductionist ideas to their (il)logical conclusion, the joke is self-explanatory enough that you don't need to have knowledge of reductionism going in.
Points are deducted for that SUPER lame explanation of "R", though. At least specify that it's a consonant.
This comic also has a weird tonal disconnect. It starts off with "judgemental and smug" etc, but then suddenly goes into "appreciate that they way you are interpreted is your responsibility" and "understand...". Then it's "vindictive about... proxies for race", but THEN it swings back to "fun to cheer on". See how they don't really form a united statement?
What I think happened is that Randy started off on one side of the fence, but then thought "hang on, I'm on to something!" and tried to make a short version of a thesis paper on the subject. (Honesty time: I would totally read the full version)
If Randy had picked either "they're both bad" or "they're both good", then that could have been a coherent argument in joke form and I would be able to judge that. As it is, this comic fails to make a concrete statement. Even if it was on one side, the bullet point structure is too direct, almost confrontational, to be comedy without alterations.
I will grant that the original observation is still interesting. However, the real interesting discussion is in how the two groups share root origins or are unconciously operating the same function in different ways. This is the hypothesis, we need the data analysis and conclusion.